Inhibition of rat embryo histidine decarboxylase by epoxyquinomicins.
نویسندگان
چکیده
epoxyquinomicins A, B, C, and D, respectively. Therefore, these epoxyquinomicins are unique candidates for antiinflammatory agents. The modeof action appears to be different from that of common NSAIDs(non-steroidal antiinflammatory drugs)3), since epoxyquinomicins C and D did not inhibit cyclooxygenase-1 at the concentration of 300 /iu. The mechanism of the antiarthritic effect has not been elucidated for epoxyquinomicins. Histidine decarboxylase is considered to be involved in the mechanism of inflammation by producing histamine. Lecanoric acid was isolated from a fungus as a histidine decarboxylase inhibitor4^. A synthetic analogue, SD-170
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 53 6 شماره
صفحات -
تاریخ انتشار 2000